Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1)
Homo sapiens — UniProt Q96RQ3
Data last refreshed: (UniProt release unknown)
Key facts
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1) is a protein from Homo sapiens identified by UniProt accession Q96RQ3, 725 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q96RQ3; gene symbol MCCC1.
- Organism: Homo sapiens.
- Length: 725 amino acids.
- Top disease associations (Open Targets): Isolated 3-methylcrotonyl-CoA carboxylase deficiency, 3-methylcrotonyl-CoA carboxylase deficiency and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial |
|---|---|
| UniProt accession | Q96RQ3 |
| Gene | MCCC1 |
| Organism | Homo sapiens |
| Length | 725 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- Isolated 3-methylcrotonyl-CoA carboxylase deficiency · score 0.82
- 3-methylcrotonyl-CoA carboxylase deficiency · score 0.73
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.39
- lymphocyte count · score 0.32
- Parkinson disease · score 0.30
- pancreatic adenocarcinoma · score 0.18
- blood metabolite measurement · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- age-related macular degeneration · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RQ3-F1 | alphafold | PREDICTED | 87.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RQ3.
Amino-acid sequence (725 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCCC1?
The strongest Open Targets associations for MCCC1 are Isolated 3-methylcrotonyl-CoA carboxylase deficiency, 3-methylcrotonyl-CoA carboxylase deficiency, genetic disorder, neurodegenerative disease and lymphocyte count.
How long is the MCCC1 protein?
The Homo sapiens MCCC1 protein (UniProt Q96RQ3) is 725 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RQ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RQ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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