Tribbles homolog 3 (TRIB3)
Homo sapiens — UniProt Q96RU7
Data last refreshed: (UniProt release unknown)
Key facts
Tribbles homolog 3 (TRIB3) is a protein from Homo sapiens identified by UniProt accession Q96RU7, 358 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.
- UniProt accession: Q96RU7; gene symbol TRIB3.
- Organism: Homo sapiens.
- Length: 358 amino acids.
- Top disease associations (Open Targets): thyroid gland adenocarcinoma, breast adenocarcinoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tribbles homolog 3 |
|---|---|
| UniProt accession | Q96RU7 |
| Gene | TRIB3 |
| Organism | Homo sapiens |
| Length | 358 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (191)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- endometrial cancer · score 0.27
- lung adenocarcinoma · score 0.25
- neoplasm · score 0.11
- cancer · score 0.11
- hepatocellular carcinoma · score 0.10
- renal cell carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RU7-F1 | alphafold | PREDICTED | 77.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RU7.
Amino-acid sequence (358 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIB3?
The strongest Open Targets associations for TRIB3 are thyroid gland adenocarcinoma, breast adenocarcinoma, ovarian cancer, endometrial cancer and lung adenocarcinoma.
How long is the TRIB3 protein?
The Homo sapiens TRIB3 protein (UniProt Q96RU7) is 358 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RU7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RU7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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