Tribbles homolog 1 (TRIB1)
Homo sapiens — UniProt Q96RU8
Data last refreshed: (UniProt release unknown)
Key facts
Tribbles homolog 1 (TRIB1) is a protein from Homo sapiens identified by UniProt accession Q96RU8, 372 residues long. MolForge cross-references it against 0 known binders and 308 disease associations.
- UniProt accession: Q96RU8; gene symbol TRIB1.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tribbles homolog 1 |
|---|---|
| UniProt accession | Q96RU8 |
| Gene | TRIB1 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (308)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- triglyceride measurement · score 0.50
- high density lipoprotein cholesterol measurement · score 0.49
- low density lipoprotein cholesterol measurement · score 0.47
- total cholesterol measurement · score 0.47
- BMI-adjusted waist-hip ratio · score 0.46
- serum alanine aminotransferase measurement · score 0.46
- alcohol consumption measurement · score 0.46
- alkaline phosphatase measurement · score 0.45
- mean corpuscular hemoglobin concentration · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RU8-F1 | alphafold | PREDICTED | 76.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RU8.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIB1?
The strongest Open Targets associations for TRIB1 are neurodegenerative disease, triglyceride measurement, high density lipoprotein cholesterol measurement, low density lipoprotein cholesterol measurement and total cholesterol measurement.
How long is the TRIB1 protein?
The Homo sapiens TRIB1 protein (UniProt Q96RU8) is 372 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RU8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RU8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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