Transcription factor ATOH8 (ATOH8)
Homo sapiens — UniProt Q96SQ7
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor ATOH8 (ATOH8) is a protein from Homo sapiens identified by UniProt accession Q96SQ7, 321 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q96SQ7; gene symbol ATOH8.
- Organism: Homo sapiens.
- Length: 321 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, multiple sclerosis and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor ATOH8 |
|---|---|
| UniProt accession | Q96SQ7 |
| Gene | ATOH8 |
| Organism | Homo sapiens |
| Length | 321 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- multiple sclerosis · score 0.36
- Alzheimer disease · score 0.36
- lysosomal storage disease · score 0.36
- Parkinson disease · score 0.36
- optic disc size measurement · score 0.29
- homocysteine measurement · score 0.27
- blood metabolite measurement · score 0.27
- disease progression measurement · score 0.27
- metastasis measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96SQ7-F1 | alphafold | PREDICTED | 64.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96SQ7.
Amino-acid sequence (321 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATOH8?
The strongest Open Targets associations for ATOH8 are neurodegenerative disease, multiple sclerosis, Alzheimer disease, lysosomal storage disease and Parkinson disease.
How long is the ATOH8 protein?
The Homo sapiens ATOH8 protein (UniProt Q96SQ7) is 321 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96SQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96SQ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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