About Mitochondrial tRNA methylthiotransferase CDK5RAP1
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1) is a protein
from Homo sapiens identified by UniProt accession
Q96SZ6, 601 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (45)
Diseases linked to this target (Open Targets).
- BMI-adjusted hip circumference · score 0.16
- body height · score 0.11
- non-melanoma skin carcinoma · score 0.11
- serum albumin measurement · score 0.09
- mean reticulocyte volume · score 0.09
- benign prostatic hyperplasia · score 0.07
- cancer · score 0.07
- blood protein measurement · score 0.06
- HMG CoA reductase inhibitor use measurement · score 0.06
- hair color · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q96SZ6.
Amino-acid sequence (601 residues)
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQVFLPPRPP KVLGLQGLKE VTLLGQNVNS FRDNSEVQFN SAVPTNLSRG FTTNYKTKQG GLRFAHLLDQ VSRVDPEMRI RFTSPHPKDF PDEVLQLIHE RDNICKQIHL PAQSGSSRVL EAMRRGYSRE AYVELVHHIR ESIPGVSLSS DFIAGFCGET EEDHVQTVSL LREVQYNMGF LFAYSMRQKT RAYHRLKDDV PEEVKLRRLE ELITIFREEA TKANQTSVGC TQLVLVEGLS KRSATDLCGR NDGNLKVIFP DAEMEDVNNP GLRVRAQPGD YVLVKITSAS SQTLRGHVLC RTTLRDSSAY C
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