Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1)
Homo sapiens — UniProt Q96SZ6
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1) is a protein from Homo sapiens identified by UniProt accession Q96SZ6, 601 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q96SZ6; gene symbol CDK5RAP1.
- Organism: Homo sapiens.
- Length: 601 amino acids.
- Top disease associations (Open Targets): BMI-adjusted hip circumference, body height and non-melanoma skin carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial tRNA methylthiotransferase CDK5RAP1 |
|---|---|
| UniProt accession | Q96SZ6 |
| Gene | CDK5RAP1 |
| Organism | Homo sapiens |
| Length | 601 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- BMI-adjusted hip circumference · score 0.16
- body height · score 0.11
- non-melanoma skin carcinoma · score 0.11
- serum albumin measurement · score 0.09
- mean reticulocyte volume · score 0.09
- benign prostatic hyperplasia · score 0.07
- cancer · score 0.07
- blood protein measurement · score 0.06
- HMG CoA reductase inhibitor use measurement · score 0.06
- hair color · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96SZ6-F1 | alphafold | PREDICTED | 82.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96SZ6.
Amino-acid sequence (601 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDK5RAP1?
The strongest Open Targets associations for CDK5RAP1 are BMI-adjusted hip circumference, body height, non-melanoma skin carcinoma, serum albumin measurement and mean reticulocyte volume.
How long is the CDK5RAP1 protein?
The Homo sapiens CDK5RAP1 protein (UniProt Q96SZ6) is 601 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96SZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96SZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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