Selenocysteine insertion sequence-binding protein 2 (SECISBP2)
Homo sapiens — UniProt Q96T21
Data last refreshed: (UniProt release unknown)
Key facts
Selenocysteine insertion sequence-binding protein 2 (SECISBP2) is a protein from Homo sapiens identified by UniProt accession Q96T21, 854 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q96T21; gene symbol SECISBP2.
- Organism: Homo sapiens.
- Length: 854 amino acids.
- Top disease associations (Open Targets): thyroid hormone metabolism, abnormal 1, thyroid hormone metabolism, abnormal and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Selenocysteine insertion sequence-binding protein 2 |
|---|---|
| UniProt accession | Q96T21 |
| Gene | SECISBP2 |
| Organism | Homo sapiens |
| Length | 854 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- thyroid hormone metabolism, abnormal 1 · score 0.72
- thyroid hormone metabolism, abnormal · score 0.64
- genetic disorder · score 0.19
- thoracic aortic aneurysm · score 0.18
- platelet crit · score 0.13
- endometrial cancer · score 0.12
- reticulocyte count · score 0.10
- reticulocyte measurement · score 0.08
- platelet count · score 0.08
- Obesity · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96T21-F1 | alphafold | PREDICTED | 55.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96T21.
Amino-acid sequence (854 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SECISBP2?
The strongest Open Targets associations for SECISBP2 are thyroid hormone metabolism, abnormal 1, thyroid hormone metabolism, abnormal, genetic disorder, thoracic aortic aneurysm and platelet crit.
How long is the SECISBP2 protein?
The Homo sapiens SECISBP2 protein (UniProt Q96T21) is 854 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96T21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96T21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.