Growth/differentiation factor 15 (GDF15)
Homo sapiens — UniProt Q99988
Data last refreshed: (UniProt release unknown)
Key facts
Growth/differentiation factor 15 (GDF15) is a protein from Homo sapiens identified by UniProt accession Q99988, 308 residues long. MolForge cross-references it against 0 known binders and 806 disease associations.
- UniProt accession: Q99988; gene symbol GDF15.
- Organism: Homo sapiens.
- Length: 308 amino acids.
- Top disease associations (Open Targets): growth differentiation factor 15 measurement, blood protein measurement and hyperemesis gravidarum.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Growth/differentiation factor 15 |
|---|---|
| UniProt accession | Q99988 |
| Gene | GDF15 |
| Organism | Homo sapiens |
| Length | 308 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (806)
Diseases linked to this target (Open Targets).
- growth differentiation factor 15 measurement · score 0.25
- blood protein measurement · score 0.25
- hyperemesis gravidarum · score 0.23
- hemoglobin A1 measurement · score 0.18
- coffee consumption measurement · score 0.18
- nausea and vomiting of pregnancy severity measurement · score 0.15
- alkaline phosphatase measurement · score 0.14
- ulcer disease · score 0.13
- neoplasm · score 0.12
- cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q99988-F1 | alphafold | PREDICTED | 75.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q99988.
Amino-acid sequence (308 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDF15?
The strongest Open Targets associations for GDF15 are growth differentiation factor 15 measurement, blood protein measurement, hyperemesis gravidarum, hemoglobin A1 measurement and coffee consumption measurement.
How long is the GDF15 protein?
The Homo sapiens GDF15 protein (UniProt Q99988) is 308 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q99988 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q99988 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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