Three prime repair exonuclease 2 (TREX2)

About Three prime repair exonuclease 2

Three prime repair exonuclease 2 (TREX2) is a protein from Homo sapiens identified by UniProt accession Q9BQ50, 236 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Three prime repair exonuclease 2
UniProt accession	Q9BQ50
Gene	TREX2
Organism	Homo sapiens
Length	236 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

Intellectual disability · score 0.11
neoplasm · score 0.08
dermatitis herpetiformis, familial · score 0.07
disseminated superficial actinic porokeratosis · score 0.05
Pilomatrixoma · score 0.05
mycosis fungoides · score 0.05
familial primary localized cutaneous amyloidosis · score 0.05
hereditary leiomyomatosis and renal cell cancer · score 0.05
ichthyosis, lamellar, autosomal dominant · score 0.04
Dowling-Degos disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQ50-F1	alphafold	PREDICTED	93.16	—

Amino-acid sequence (236 residues)

MSEAPRAETF VFLDLEATGL PSVEPEIAEL SLFAVHRSSL ENPEHDESGA LVLPRVLDKL TLCMCPERPF TAKASEITGL SSEGLARCRK AGFDGAVVRT LQAFLSRQAG PICLVAHNGF DYDFPLLCAE LRRLGARLPR DTVCLDTLPA LRGLDRAHSH GTRARGRQGY SLGSLFHRYF RAEPSAAHSA EGDVHTLLLI FLHRAAELLA WADEQARGWA HIEPMYLPPD DPSLEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards