Three prime repair exonuclease 2 (TREX2)
Homo sapiens — UniProt Q9BQ50
Data last refreshed: (UniProt release unknown)
Key facts
Three prime repair exonuclease 2 (TREX2) is a protein from Homo sapiens identified by UniProt accession Q9BQ50, 236 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9BQ50; gene symbol TREX2.
- Organism: Homo sapiens.
- Length: 236 amino acids.
- Top disease associations (Open Targets): Intellectual disability, neoplasm and dermatitis herpetiformis, familial.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Three prime repair exonuclease 2 |
|---|---|
| UniProt accession | Q9BQ50 |
| Gene | TREX2 |
| Organism | Homo sapiens |
| Length | 236 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.11
- neoplasm · score 0.08
- dermatitis herpetiformis, familial · score 0.07
- disseminated superficial actinic porokeratosis · score 0.05
- Pilomatrixoma · score 0.05
- mycosis fungoides · score 0.05
- familial primary localized cutaneous amyloidosis · score 0.05
- hereditary leiomyomatosis and renal cell cancer · score 0.05
- ichthyosis, lamellar, autosomal dominant · score 0.04
- Dowling-Degos disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BQ50-F1 | alphafold | PREDICTED | 93.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BQ50.
Amino-acid sequence (236 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TREX2?
The strongest Open Targets associations for TREX2 are Intellectual disability, neoplasm, dermatitis herpetiformis, familial, disseminated superficial actinic porokeratosis and Pilomatrixoma.
How long is the TREX2 protein?
The Homo sapiens TREX2 protein (UniProt Q9BQ50) is 236 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BQ50 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BQ50 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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