Apolipoprotein L2 (APOL2)

About Apolipoprotein L2

Apolipoprotein L2 (APOL2) is a protein from Homo sapiens identified by UniProt accession Q9BQE5, 337 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Apolipoprotein L2
UniProt accession	Q9BQE5
Gene	APOL2
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.21
diabetic nephropathy · score 0.21
chronic kidney disease · score 0.14
inflammatory bowel disease · score 0.12
mean corpuscular volume · score 0.04
reticulocyte measurement · score 0.04
heel bone mineral density · score 0.04
mean corpuscular hemoglobin · score 0.04
Red cell distribution width · score 0.03
focal segmental glomerulosclerosis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQE5-F1	alphafold	PREDICTED	52.51	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BQE5.

Amino-acid sequence (337 residues)

MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD ELRKALNKLA SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR ALAEEVEQVH RGTTIANVVS NSVGTTSGIL TLLGLGLAPF TEGISFVLLD TGMGLGAAAA VAGITCSVVE LVNKLRARAQ ARNLDQSGTN VAKVMKEFVG GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA PPPHVIGRIS AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards