Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
Homo sapiens — UniProt Q9BQI3
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) is a protein from Homo sapiens identified by UniProt accession Q9BQI3, 630 residues long. MolForge cross-references it against 6 known binders and 164 disease associations.
- UniProt accession: Q9BQI3; gene symbol EIF2AK1.
- Organism: Homo sapiens.
- Length: 630 amino acids.
- Top disease associations (Open Targets): reticulocyte measurement, reticulocyte count and Immature Reticulocyte Fraction Measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic translation initiation factor 2-alpha kinase 1 |
|---|---|
| UniProt accession | Q9BQI3 |
| Gene | EIF2AK1 |
| Organism | Homo sapiens |
| Length | 630 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (164)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.62
- reticulocyte count · score 0.59
- Immature Reticulocyte Fraction Measurement · score 0.52
- leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome · score 0.48
- leukodystrophy, hypomyelinating, 17 · score 0.42
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.37
- mean corpuscular volume · score 0.25
- mean corpuscular hemoglobin · score 0.23
- mean corpuscular hemoglobin concentration · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BQI3-F1 | alphafold | PREDICTED | 63.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BQI3.
Amino-acid sequence (630 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF2AK1?
The strongest Open Targets associations for EIF2AK1 are reticulocyte measurement, reticulocyte count, Immature Reticulocyte Fraction Measurement, leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome and leukodystrophy, hypomyelinating, 17.
How long is the EIF2AK1 protein?
The Homo sapiens EIF2AK1 protein (UniProt Q9BQI3) is 630 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BQI3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BQI3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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