SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)
Homo sapiens — UniProt Q9BQI5
Data last refreshed: (UniProt release unknown)
Key facts
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) is a protein from Homo sapiens identified by UniProt accession Q9BQI5, 828 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9BQI5; gene symbol SGIP1.
- Organism: Homo sapiens.
- Length: 828 amino acids.
- Top disease associations (Open Targets): electrocardiography, heel bone mineral density and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH3-containing GRB2-like protein 3-interacting protein 1 |
|---|---|
| UniProt accession | Q9BQI5 |
| Gene | SGIP1 |
| Organism | Homo sapiens |
| Length | 828 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.47
- heel bone mineral density · score 0.44
- systolic blood pressure · score 0.43
- pulse pressure measurement · score 0.41
- type 2 diabetes mellitus · score 0.39
- serum gamma-glutamyl transferase measurement · score 0.37
- TPE interval measurement · score 0.36
- lifestyle measurement · score 0.35
- sunburn · score 0.33
- attention deficit hyperactivity disorder · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BQI5-F1 | alphafold | PREDICTED | 60.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BQI5.
Amino-acid sequence (828 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGIP1?
The strongest Open Targets associations for SGIP1 are electrocardiography, heel bone mineral density, systolic blood pressure, pulse pressure measurement and type 2 diabetes mellitus.
How long is the SGIP1 protein?
The Homo sapiens SGIP1 protein (UniProt Q9BQI5) is 828 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BQI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BQI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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