PH and SEC7 domain-containing protein 2 (PSD2)

About PH and SEC7 domain-containing protein 2

PH and SEC7 domain-containing protein 2 (PSD2) is a protein from Homo sapiens identified by UniProt accession Q9BQI7, 771 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	PH and SEC7 domain-containing protein 2
UniProt accession	Q9BQI7
Gene	PSD2
Organism	Homo sapiens
Length	771 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

platelet count · score 0.12
BMI-adjusted hip circumference · score 0.11
body weight · score 0.07
lean body mass · score 0.06
fat body mass · score 0.05
appendicular lean mass · score 0.04
peak expiratory flow · score 0.04
base metabolic rate measurement · score 0.04
whole body water mass · score 0.04
body mass index · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BQI7-F1	alphafold	PREDICTED	61.62	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BQI7.

Amino-acid sequence (771 residues)

MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER RGTPADTEEP TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR AGVLAEGDNA SRSLYPDAED PQLGLDGPGE PDVRDGFSAT FEKILESELL RGTQYSSLDS LDGLSLTDES DSCVSFEAPL TPLIQQRARD SPEPGAGLGI GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL MAMPNGFHED GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY LSFFDFSGLT LDGALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS TSEDGIHTLT CALMLLNTDL HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD LLKTLYNSIK NEKLEWAIDE DELRKSLSEL VDDKFGTGTK KVTRILDGGN PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK KFYAVLKGTI LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC TTRLCQEEQL RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY LTFEKSRYET YIHLLAMKIK VGSDDLERIE ARLATLEGDD PSLRKTHSSP ALSQGHVTGS KTTKDATGPD T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards