Zinc finger SWIM domain-containing protein 1 (ZSWIM1)
Homo sapiens — UniProt Q9BR11
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger SWIM domain-containing protein 1 (ZSWIM1) is a protein from Homo sapiens identified by UniProt accession Q9BR11, 485 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.
- UniProt accession: Q9BR11; gene symbol ZSWIM1.
- Organism: Homo sapiens.
- Length: 485 amino acids.
- Top disease associations (Open Targets): mean platelet volume, body height and Blackfan-Diamond anemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger SWIM domain-containing protein 1 |
|---|---|
| UniProt accession | Q9BR11 |
| Gene | ZSWIM1 |
| Organism | Homo sapiens |
| Length | 485 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (210)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.13
- body height · score 0.08
- Blackfan-Diamond anemia · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- neutrophil immunodeficiency syndrome · score 0.05
- alpha-thalassemia-myelodysplastic syndrome · score 0.05
- Familial hemophagocytic lymphohistiocytosis · score 0.05
- X-linked severe congenital neutropenia · score 0.05
- refractory anemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BR11-F1 | alphafold | PREDICTED | 75.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BR11.
Amino-acid sequence (485 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZSWIM1?
The strongest Open Targets associations for ZSWIM1 are mean platelet volume, body height, Blackfan-Diamond anemia, primary familial polycythemia due to EPO receptor mutation and beta-thalassemia-X-linked thrombocytopenia syndrome.
How long is the ZSWIM1 protein?
The Homo sapiens ZSWIM1 protein (UniProt Q9BR11) is 485 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BR11 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BR11 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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