Junctophilin-2 (JPH2)
Homo sapiens — UniProt Q9BR39
Data last refreshed: (UniProt release unknown)
Key facts
Junctophilin-2 (JPH2) is a protein from Homo sapiens identified by UniProt accession Q9BR39, 696 residues long. MolForge cross-references it against 0 known binders and 202 disease associations.
- UniProt accession: Q9BR39; gene symbol JPH2.
- Organism: Homo sapiens.
- Length: 696 amino acids.
- Top disease associations (Open Targets): hypertrophic cardiomyopathy 17, hypertrophic cardiomyopathy and Rare familial disorder with hypertrophic cardiomyopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Junctophilin-2 |
|---|---|
| UniProt accession | Q9BR39 |
| Gene | JPH2 |
| Organism | Homo sapiens |
| Length | 696 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (202)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy 17 · score 0.75
- hypertrophic cardiomyopathy · score 0.71
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.49
- systolic blood pressure · score 0.47
- dilated cardiomyopathy · score 0.46
- mean arterial pressure · score 0.44
- pulse pressure measurement · score 0.43
- Diuretic use measurement · score 0.40
- Calcium channel blocker use measurement · score 0.39
- Agents acting on the renin-angiotensin system use measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BR39-F1 | alphafold | PREDICTED | 64.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BR39.
Amino-acid sequence (696 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JPH2?
The strongest Open Targets associations for JPH2 are hypertrophic cardiomyopathy 17, hypertrophic cardiomyopathy, Rare familial disorder with hypertrophic cardiomyopathy, systolic blood pressure and dilated cardiomyopathy.
How long is the JPH2 protein?
The Homo sapiens JPH2 protein (UniProt Q9BR39) is 696 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BR39 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BR39 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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