Coiled-coil domain-containing protein 77 (CCDC77)
Homo sapiens — UniProt Q9BR77
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 77 (CCDC77) is a protein from Homo sapiens identified by UniProt accession Q9BR77, 488 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9BR77; gene symbol CCDC77.
- Organism: Homo sapiens.
- Length: 488 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pulse pressure measurement and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 77 |
|---|---|
| UniProt accession | Q9BR77 |
| Gene | CCDC77 |
| Organism | Homo sapiens |
| Length | 488 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- pulse pressure measurement · score 0.27
- PHF-tau measurement · score 0.19
- serum alanine aminotransferase measurement · score 0.15
- BMI-adjusted waist-hip ratio · score 0.14
- systolic blood pressure · score 0.05
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- platelet crit · score 0.04
- Combined hyperlipidemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BR77-F1 | alphafold | PREDICTED | 79.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BR77.
Amino-acid sequence (488 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC77?
The strongest Open Targets associations for CCDC77 are neurodegenerative disease, pulse pressure measurement, PHF-tau measurement, serum alanine aminotransferase measurement and BMI-adjusted waist-hip ratio.
How long is the CCDC77 protein?
The Homo sapiens CCDC77 protein (UniProt Q9BR77) is 488 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BR77 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BR77 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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