Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (PIGQ)
Homo sapiens — UniProt Q9BRB3
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (PIGQ) is a protein from Homo sapiens identified by UniProt accession Q9BRB3, 760 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9BRB3; gene symbol PIGQ.
- Organism: Homo sapiens.
- Length: 760 amino acids.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, epilepsy and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q |
|---|---|
| UniProt accession | Q9BRB3 |
| Gene | PIGQ |
| Organism | Homo sapiens |
| Length | 760 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.61
- epilepsy · score 0.55
- genetic disorder · score 0.50
- neurodegenerative disease · score 0.37
- Global developmental delay · score 0.26
- Seizure · score 0.26
- optic atrophy · score 0.26
- Red cell distribution width · score 0.23
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin concentration · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRB3-F1 | alphafold | PREDICTED | 64.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRB3.
Amino-acid sequence (760 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGQ?
The strongest Open Targets associations for PIGQ are developmental and epileptic encephalopathy, epilepsy, genetic disorder, neurodegenerative disease and Global developmental delay.
How long is the PIGQ protein?
The Homo sapiens PIGQ protein (UniProt Q9BRB3) is 760 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRB3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRB3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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