Vacuolar protein-sorting-associated protein 25 (VPS25)
Homo sapiens — UniProt Q9BRG1
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein-sorting-associated protein 25 (VPS25) is a protein from Homo sapiens identified by UniProt accession Q9BRG1, 176 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q9BRG1; gene symbol VPS25.
- Organism: Homo sapiens.
- Length: 176 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, viral disease and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein-sorting-associated protein 25 |
|---|---|
| UniProt accession | Q9BRG1 |
| Gene | VPS25 |
| Organism | Homo sapiens |
| Length | 176 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- viral disease · score 0.46
- BMI-adjusted waist-hip ratio · score 0.11
- Syndactyly type 2 · score 0.05
- syndactyly type 4 · score 0.05
- pulse pressure measurement · score 0.04
- mesomelic dwarfism-cleft palate-camptodactyly syndrome · score 0.04
- Triphalangeal thumb - polysyndactyly syndrome · score 0.04
- polydactyly of a triphalangeal thumb · score 0.04
- synpolydactyly type 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRG1-F1 | alphafold | PREDICTED | 92.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRG1.
Amino-acid sequence (176 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS25?
The strongest Open Targets associations for VPS25 are neurodegenerative disease, viral disease, BMI-adjusted waist-hip ratio, Syndactyly type 2 and syndactyly type 4.
How long is the VPS25 protein?
The Homo sapiens VPS25 protein (UniProt Q9BRG1) is 176 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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