SH2 domain-containing protein 3A (SH2D3A)
Homo sapiens — UniProt Q9BRG2
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing protein 3A (SH2D3A) is a protein from Homo sapiens identified by UniProt accession Q9BRG2, 576 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q9BRG2; gene symbol SH2D3A.
- Organism: Homo sapiens.
- Length: 576 amino acids.
- Top disease associations (Open Targets): infection, infect and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing protein 3A |
|---|---|
| UniProt accession | Q9BRG2 |
| Gene | SH2D3A |
| Organism | Homo sapiens |
| Length | 576 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- infection · score 0.07
- infect · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.06
- mean platelet volume · score 0.04
- platelet component distribution width · score 0.03
- platelet count · score 0.03
- viral disease · score 0.03
- COVID-19 · score 0.02
- hypertension · score 0.02
- rotavirus infection · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRG2-F1 | alphafold | PREDICTED | 76.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRG2.
Amino-acid sequence (576 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2D3A?
The strongest Open Targets associations for SH2D3A are infection, infect, serum gamma-glutamyl transferase measurement, mean platelet volume and platelet component distribution width.
How long is the SH2D3A protein?
The Homo sapiens SH2D3A protein (UniProt Q9BRG2) is 576 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRG2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRG2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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