Zinc finger protein 251 (ZNF251)
Homo sapiens — UniProt Q9BRH9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 251 (ZNF251) is a protein from Homo sapiens identified by UniProt accession Q9BRH9, 671 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9BRH9; gene symbol ZNF251.
- Organism: Homo sapiens.
- Length: 671 amino acids.
- Top disease associations (Open Targets): serum alanine aminotransferase measurement, type 2 diabetes mellitus and MODY.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 251 |
|---|---|
| UniProt accession | Q9BRH9 |
| Gene | ZNF251 |
| Organism | Homo sapiens |
| Length | 671 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.34
- type 2 diabetes mellitus · score 0.10
- MODY · score 0.07
- diabetes mellitus · score 0.05
- transient neonatal diabetes mellitus · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.04
- permanent neonatal diabetes mellitus 1 · score 0.04
- hyperproinsulinemia · score 0.03
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.03
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRH9-F1 | alphafold | PREDICTED | 63.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRH9.
Amino-acid sequence (671 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF251?
The strongest Open Targets associations for ZNF251 are serum alanine aminotransferase measurement, type 2 diabetes mellitus, MODY, diabetes mellitus and transient neonatal diabetes mellitus.
How long is the ZNF251 protein?
The Homo sapiens ZNF251 protein (UniProt Q9BRH9) is 671 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRH9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRH9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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