Receptor expression-enhancing protein 2 (REEP2)
Homo sapiens — UniProt Q9BRK0
Data last refreshed: (UniProt release unknown)
Key facts
Receptor expression-enhancing protein 2 (REEP2) is a protein from Homo sapiens identified by UniProt accession Q9BRK0, 252 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9BRK0; gene symbol REEP2.
- Organism: Homo sapiens.
- Length: 252 amino acids.
- Top disease associations (Open Targets): Autosomal recessive spastic paraplegia type 72, hereditary spastic paraplegia 72 and small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Receptor expression-enhancing protein 2 |
|---|---|
| UniProt accession | Q9BRK0 |
| Gene | REEP2 |
| Organism | Homo sapiens |
| Length | 252 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 72 · score 0.67
- hereditary spastic paraplegia 72 · score 0.67
- small cell lung carcinoma · score 0.18
- retinoblastoma · score 0.18
- urinary bladder cancer · score 0.18
- hereditary retinoblastoma · score 0.18
- bone osteosarcoma · score 0.18
- retinoblastoma (nonhereditary) · score 0.18
- ovarian cancer · score 0.18
- genetic disorder · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRK0-F1 | alphafold | PREDICTED | 64.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRK0.
Amino-acid sequence (252 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REEP2?
The strongest Open Targets associations for REEP2 are Autosomal recessive spastic paraplegia type 72, hereditary spastic paraplegia 72, small cell lung carcinoma, retinoblastoma and urinary bladder cancer.
How long is the REEP2 protein?
The Homo sapiens REEP2 protein (UniProt Q9BRK0) is 252 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRK0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRK0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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