Matrix remodeling-associated protein 8 (MXRA8)
Homo sapiens — UniProt Q9BRK3
Data last refreshed: (UniProt release unknown)
Key facts
Matrix remodeling-associated protein 8 (MXRA8) is a protein from Homo sapiens identified by UniProt accession Q9BRK3, 442 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9BRK3; gene symbol MXRA8.
- Organism: Homo sapiens.
- Length: 442 amino acids.
- Top disease associations (Open Targets): Abnormal brain morphology, systolic blood pressure and intraocular pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Matrix remodeling-associated protein 8 |
|---|---|
| UniProt accession | Q9BRK3 |
| Gene | MXRA8 |
| Organism | Homo sapiens |
| Length | 442 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- Abnormal brain morphology · score 0.27
- systolic blood pressure · score 0.15
- intraocular pressure measurement · score 0.14
- sitting height measurement · score 0.13
- osteoporosis · score 0.11
- neoplasm · score 0.10
- breast cancer · score 0.08
- myxedema · score 0.06
- infection · score 0.06
- infect · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRK3-F1 | alphafold | PREDICTED | 75.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRK3.
Amino-acid sequence (442 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MXRA8?
The strongest Open Targets associations for MXRA8 are Abnormal brain morphology, systolic blood pressure, intraocular pressure measurement, sitting height measurement and osteoporosis.
How long is the MXRA8 protein?
The Homo sapiens MXRA8 protein (UniProt Q9BRK3) is 442 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRK3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRK3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.