Leucine zipper putative tumor suppressor 2 (LZTS2)
Homo sapiens — UniProt Q9BRK4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine zipper putative tumor suppressor 2 (LZTS2) is a protein from Homo sapiens identified by UniProt accession Q9BRK4, 669 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9BRK4; gene symbol LZTS2.
- Organism: Homo sapiens.
- Length: 669 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mitochondrial heteroplasmy measurement and mitochondrial DNA measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine zipper putative tumor suppressor 2 |
|---|---|
| UniProt accession | Q9BRK4 |
| Gene | LZTS2 |
| Organism | Homo sapiens |
| Length | 669 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- mitochondrial heteroplasmy measurement · score 0.15
- mitochondrial DNA measurement · score 0.12
- diabetes mellitus · score 0.12
- serum gamma-glutamyl transferase measurement · score 0.11
- smoking status measurement · score 0.10
- hepatocellular carcinoma · score 0.08
- triple-negative breast cancer · score 0.07
- blood phosphate measurement · score 0.07
- mean platelet volume · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRK4-F1 | alphafold | PREDICTED | 65.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRK4.
Amino-acid sequence (669 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LZTS2?
The strongest Open Targets associations for LZTS2 are neurodegenerative disease, mitochondrial heteroplasmy measurement, mitochondrial DNA measurement, diabetes mellitus and serum gamma-glutamyl transferase measurement.
How long is the LZTS2 protein?
The Homo sapiens LZTS2 protein (UniProt Q9BRK4) is 669 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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