TM2 domain-containing protein 3 (TM2D3)
Homo sapiens — UniProt Q9BRN9
Data last refreshed: (UniProt release unknown)
Key facts
TM2 domain-containing protein 3 (TM2D3) is a protein from Homo sapiens identified by UniProt accession Q9BRN9, 247 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9BRN9; gene symbol TM2D3.
- Organism: Homo sapiens.
- Length: 247 amino acids.
- Top disease associations (Open Targets): Alzheimer disease type 1, neurodegenerative disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TM2 domain-containing protein 3 |
|---|---|
| UniProt accession | Q9BRN9 |
| Gene | TM2D3 |
| Organism | Homo sapiens |
| Length | 247 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- Alzheimer disease type 1 · score 0.37
- neurodegenerative disease · score 0.30
- Alzheimer disease · score 0.12
- frontotemporal dementia · score 0.12
- Lipedema · score 0.04
- adolescent idiopathic scoliosis · score 0.04
- Lymphedema - cerebral arteriovenous anomaly · score 0.04
- lymphedema-cerebral arteriovenous anomaly syndrome · score 0.04
- lymphatic malformation 8 · score 0.04
- Milroy disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRN9-F1 | alphafold | PREDICTED | 79.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRN9.
Amino-acid sequence (247 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TM2D3?
The strongest Open Targets associations for TM2D3 are Alzheimer disease type 1, neurodegenerative disease, Alzheimer disease, frontotemporal dementia and Lipedema.
How long is the TM2D3 protein?
The Homo sapiens TM2D3 protein (UniProt Q9BRN9) is 247 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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