Transcription factor Ovo-like 2 (OVOL2)
Homo sapiens — UniProt Q9BRP0
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Ovo-like 2 (OVOL2) is a protein from Homo sapiens identified by UniProt accession Q9BRP0, 275 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q9BRP0; gene symbol OVOL2.
- Organism: Homo sapiens.
- Length: 275 amino acids.
- Top disease associations (Open Targets): posterior polymorphous corneal dystrophy, mean corpuscular volume and red blood cell density measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Ovo-like 2 |
|---|---|
| UniProt accession | Q9BRP0 |
| Gene | OVOL2 |
| Organism | Homo sapiens |
| Length | 275 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- posterior polymorphous corneal dystrophy · score 0.58
- mean corpuscular volume · score 0.41
- red blood cell density measurement · score 0.39
- erythrocyte count · score 0.39
- mean corpuscular hemoglobin · score 0.38
- DNA methylation · score 0.33
- mean corpuscular hemoglobin concentration · score 0.30
- mitochondrial DNA measurement · score 0.24
- low density lipoprotein cholesterol measurement · score 0.15
- total cholesterol measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRP0-F1 | alphafold | PREDICTED | 60.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRP0.
Amino-acid sequence (275 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OVOL2?
The strongest Open Targets associations for OVOL2 are posterior polymorphous corneal dystrophy, mean corpuscular volume, red blood cell density measurement, erythrocyte count and mean corpuscular hemoglobin.
How long is the OVOL2 protein?
The Homo sapiens OVOL2 protein (UniProt Q9BRP0) is 275 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRP0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRP0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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