Pygopus homolog 2 (PYGO2)
Homo sapiens — UniProt Q9BRQ0
Data last refreshed: (UniProt release unknown)
Key facts
Pygopus homolog 2 (PYGO2) is a protein from Homo sapiens identified by UniProt accession Q9BRQ0, 406 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q9BRQ0; gene symbol PYGO2.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pygopus homolog 2 |
|---|---|
| UniProt accession | Q9BRQ0 |
| Gene | PYGO2 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- endometrial cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.10
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
- insulin like growth factor measurement · score 0.10
- erythrocyte count · score 0.05
- gonorrhea · score 0.05
- brain glioma · score 0.04
- congenital primary aphakia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRQ0-F1 | alphafold | PREDICTED | 55.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRQ0.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PYGO2?
The strongest Open Targets associations for PYGO2 are neurodegenerative disease, endometrial cancer, head and neck squamous cell carcinoma, neoplasm and hepatocellular carcinoma.
How long is the PYGO2 protein?
The Homo sapiens PYGO2 protein (UniProt Q9BRQ0) is 406 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRQ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRQ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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