Cilia- and flagella-associated protein 300 (CFAP300)
Homo sapiens — UniProt Q9BRQ4
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 300 (CFAP300) is a protein from Homo sapiens identified by UniProt accession Q9BRQ4, 267 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9BRQ4; gene symbol CFAP300.
- Organism: Homo sapiens.
- Length: 267 amino acids.
- Top disease associations (Open Targets): ciliary dyskinesia, primary, 38, primary ciliary dyskinesia and Heterotaxy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 300 |
|---|---|
| UniProt accession | Q9BRQ4 |
| Gene | CFAP300 |
| Organism | Homo sapiens |
| Length | 267 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- ciliary dyskinesia, primary, 38 · score 0.67
- primary ciliary dyskinesia · score 0.50
- Heterotaxy · score 0.33
- PHF-tau measurement · score 0.30
- risk-taking behaviour · score 0.21
- genetic disorder · score 0.16
- Gorham-Stout disease · score 0.07
- platelet count · score 0.07
- melorheostosis · score 0.05
- sex hormone-binding globulin measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRQ4-F1 | alphafold | PREDICTED | 93.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRQ4.
Amino-acid sequence (267 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP300?
The strongest Open Targets associations for CFAP300 are ciliary dyskinesia, primary, 38, primary ciliary dyskinesia, Heterotaxy, PHF-tau measurement and risk-taking behaviour.
How long is the CFAP300 protein?
The Homo sapiens CFAP300 protein (UniProt Q9BRQ4) is 267 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRQ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRQ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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