Protein orai-3 (ORAI3)
Homo sapiens — UniProt Q9BRQ5
Data last refreshed: (UniProt release unknown)
Key facts
Protein orai-3 (ORAI3) is a protein from Homo sapiens identified by UniProt accession Q9BRQ5, 295 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9BRQ5; gene symbol ORAI3.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): basophil percentage of leukocytes, age-related macular degeneration and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein orai-3 |
|---|---|
| UniProt accession | Q9BRQ5 |
| Gene | ORAI3 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- basophil percentage of leukocytes · score 0.38
- age-related macular degeneration · score 0.08
- neoplasm · score 0.08
- oral squamous cell carcinoma · score 0.08
- Rheumatoid arthritis · score 0.08
- pachyonychia congenita · score 0.08
- X-linked retinal dysplasia · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- retinitis pigmentosa · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRQ5-F1 | alphafold | PREDICTED | 71.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRQ5.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ORAI3?
The strongest Open Targets associations for ORAI3 are basophil percentage of leukocytes, age-related macular degeneration, neoplasm, oral squamous cell carcinoma and Rheumatoid arthritis.
How long is the ORAI3 protein?
The Homo sapiens ORAI3 protein (UniProt Q9BRQ5) is 295 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.