Ferroptosis suppressor protein 1 (AIFM2)
Homo sapiens — UniProt Q9BRQ8
Data last refreshed: (UniProt release unknown)
Key facts
Ferroptosis suppressor protein 1 (AIFM2) is a protein from Homo sapiens identified by UniProt accession Q9BRQ8, 373 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q9BRQ8; gene symbol AIFM2.
- Organism: Homo sapiens.
- Length: 373 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, rheumatoid arthritis and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ferroptosis suppressor protein 1 |
|---|---|
| UniProt accession | Q9BRQ8 |
| Gene | AIFM2 |
| Organism | Homo sapiens |
| Length | 373 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.32
- rheumatoid arthritis · score 0.27
- high density lipoprotein cholesterol measurement · score 0.27
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- gastric adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- endometrial cancer · score 0.23
- cutaneous melanoma · score 0.12
- waist-hip ratio · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRQ8-F1 | alphafold | PREDICTED | 95.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRQ8.
Amino-acid sequence (373 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AIFM2?
The strongest Open Targets associations for AIFM2 are BMI-adjusted waist-hip ratio, rheumatoid arthritis, high density lipoprotein cholesterol measurement, breast adenocarcinoma and head and neck squamous cell carcinoma.
How long is the AIFM2 protein?
The Homo sapiens AIFM2 protein (UniProt Q9BRQ8) is 373 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRQ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRQ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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