GPI-N-acetylgalactosamine transferase PGAP4 (PGAP4)
Homo sapiens — UniProt Q9BRR3
Data last refreshed: (UniProt release unknown)
Key facts
GPI-N-acetylgalactosamine transferase PGAP4 (PGAP4) is a protein from Homo sapiens identified by UniProt accession Q9BRR3, 403 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q9BRR3; gene symbol PGAP4.
- Organism: Homo sapiens.
- Length: 403 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, protein measurement and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI-N-acetylgalactosamine transferase PGAP4 |
|---|---|
| UniProt accession | Q9BRR3 |
| Gene | PGAP4 |
| Organism | Homo sapiens |
| Length | 403 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.28
- protein measurement · score 0.20
- alkaline phosphatase measurement · score 0.19
- mean corpuscular hemoglobin concentration · score 0.06
- mean corpuscular hemoglobin · score 0.06
- Hypocalcemic vitamin D-dependent rickets · score 0.05
- mean corpuscular volume · score 0.05
- X-linked hypophosphatemia · score 0.05
- Hypocalcemic vitamin D-resistant rickets · score 0.05
- Metaphyseal chondrodysplasia, Schmid type · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRR3-F1 | alphafold | PREDICTED | 87.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRR3.
Amino-acid sequence (403 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PGAP4?
The strongest Open Targets associations for PGAP4 are neurofibrillary tangles measurement, protein measurement, alkaline phosphatase measurement, mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin.
How long is the PGAP4 protein?
The Homo sapiens PGAP4 protein (UniProt Q9BRR3) is 403 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRR3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRR3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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