G patch domain-containing protein 1 (GPATCH1)
Homo sapiens — UniProt Q9BRR8
Data last refreshed: (UniProt release unknown)
Key facts
G patch domain-containing protein 1 (GPATCH1) is a protein from Homo sapiens identified by UniProt accession Q9BRR8, 931 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9BRR8; gene symbol GPATCH1.
- Organism: Homo sapiens.
- Length: 931 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, heel bone mineral density and bone quantitative ultrasound measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G patch domain-containing protein 1 |
|---|---|
| UniProt accession | Q9BRR8 |
| Gene | GPATCH1 |
| Organism | Homo sapiens |
| Length | 931 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- heel bone mineral density · score 0.30
- bone quantitative ultrasound measurement · score 0.25
- colorectal cancer · score 0.24
- bone density · score 0.23
- serum gamma-glutamyl transferase measurement · score 0.18
- alkaline phosphatase measurement · score 0.18
- brain volume measurement · score 0.15
- neuroimaging measurement · score 0.15
- velocity of sound measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRR8-F1 | alphafold | PREDICTED | 59.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRR8.
Amino-acid sequence (931 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPATCH1?
The strongest Open Targets associations for GPATCH1 are neurodegenerative disease, heel bone mineral density, bone quantitative ultrasound measurement, colorectal cancer and bone density.
How long is the GPATCH1 protein?
The Homo sapiens GPATCH1 protein (UniProt Q9BRR8) is 931 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRR8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRR8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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