Rho GTPase-activating protein 9 (ARHGAP9)
Homo sapiens — UniProt Q9BRR9
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 9 (ARHGAP9) is a protein from Homo sapiens identified by UniProt accession Q9BRR9, 750 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9BRR9; gene symbol ARHGAP9.
- Organism: Homo sapiens.
- Length: 750 amino acids.
- Top disease associations (Open Targets): spastic paraplegia 70, autosomal recessive, severe early-onset pulmonary alveolar proteinosis due to MARS deficiency and Charcot-Marie-Tooth disease axonal type 2U.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 9 |
|---|---|
| UniProt accession | Q9BRR9 |
| Gene | ARHGAP9 |
| Organism | Homo sapiens |
| Length | 750 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- spastic paraplegia 70, autosomal recessive · score 0.33
- severe early-onset pulmonary alveolar proteinosis due to MARS deficiency · score 0.19
- Charcot-Marie-Tooth disease axonal type 2U · score 0.19
- triglyceride measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.16
- aspartate aminotransferase measurement · score 0.15
- inflammatory bowel disease · score 0.12
- hereditary spastic paraplegia · score 0.12
- platelet crit · score 0.10
- acute myeloid leukemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRR9-F1 | alphafold | PREDICTED | 66.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRR9.
Amino-acid sequence (750 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP9?
The strongest Open Targets associations for ARHGAP9 are spastic paraplegia 70, autosomal recessive, severe early-onset pulmonary alveolar proteinosis due to MARS deficiency, Charcot-Marie-Tooth disease axonal type 2U, triglyceride measurement and high density lipoprotein cholesterol measurement.
How long is the ARHGAP9 protein?
The Homo sapiens ARHGAP9 protein (UniProt Q9BRR9) is 750 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRR9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRR9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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