Serine/threonine-protein kinase RIO1 (RIOK1)
Homo sapiens — UniProt Q9BRS2
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase RIO1 (RIOK1) is a protein from Homo sapiens identified by UniProt accession Q9BRS2, 568 residues long. MolForge cross-references it against 10 known binders and 44 disease associations.
- UniProt accession: Q9BRS2; gene symbol RIOK1.
- Organism: Homo sapiens.
- Length: 568 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase RIO1 |
|---|---|
| UniProt accession | Q9BRS2 |
| Gene | RIOK1 |
| Organism | Homo sapiens |
| Length | 568 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.08
- breast cancer · score 0.07
- glioblastoma multiforme · score 0.07
- gonorrhea · score 0.06
- cancer · score 0.05
- QRS complex · score 0.04
- QRS amplitude · score 0.04
- hemoglobin measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRS2-F1 | alphafold | PREDICTED | 68.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRS2.
Amino-acid sequence (568 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RIOK1?
The strongest Open Targets associations for RIOK1 are neurodegenerative disease, neoplasm, non-small cell lung carcinoma, breast cancer and glioblastoma multiforme.
How long is the RIOK1 protein?
The Homo sapiens RIOK1 protein (UniProt Q9BRS2) is 568 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRS2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRS2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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