Serine/threonine-protein kinase RIO1 (RIOK1)

About Serine/threonine-protein kinase RIO1

Serine/threonine-protein kinase RIO1 (RIOK1) is a protein from Homo sapiens identified by UniProt accession Q9BRS2, 568 residues long. MolForge cross-references it against 10 known binders and 44 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase RIO1
UniProt accession	Q9BRS2
Gene	RIOK1
Organism	Homo sapiens
Length	568 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
neoplasm · score 0.09
non-small cell lung carcinoma · score 0.08
breast cancer · score 0.07
glioblastoma multiforme · score 0.07
gonorrhea · score 0.06
cancer · score 0.05
QRS complex · score 0.04
QRS amplitude · score 0.04
hemoglobin measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BRS2-F1	alphafold	PREDICTED	68.77	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRS2.

Amino-acid sequence (568 residues)

MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE AQREKRKNKI PKHVKKRKEK TAKTKKGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards