Zinc-regulated GTPase metalloprotein activator 1A (ZNG1A)
Homo sapiens — UniProt Q9BRT8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc-regulated GTPase metalloprotein activator 1A (ZNG1A) is a protein from Homo sapiens identified by UniProt accession Q9BRT8, 395 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9BRT8; gene symbol ZNG1A.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): mean platelet volume, combined immunodeficiency due to DOCK8 deficiency and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc-regulated GTPase metalloprotein activator 1A |
|---|---|
| UniProt accession | Q9BRT8 |
| Gene | ZNG1A |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.36
- combined immunodeficiency due to DOCK8 deficiency · score 0.33
- platelet component distribution width · score 0.33
- hair color · score 0.15
- heel bone mineral density · score 0.13
- monocyte percentage of leukocytes · score 0.12
- platelet count · score 0.12
- systolic blood pressure · score 0.11
- nevus count · score 0.10
- balding measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRT8-F1 | alphafold | PREDICTED | 75.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRT8.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNG1A?
The strongest Open Targets associations for ZNG1A are mean platelet volume, combined immunodeficiency due to DOCK8 deficiency, platelet component distribution width, hair color and heel bone mineral density.
How long is the ZNG1A protein?
The Homo sapiens ZNG1A protein (UniProt Q9BRT8) is 395 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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