Suppressor of IKBKE 1 (SIKE1)
Homo sapiens — UniProt Q9BRV8
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of IKBKE 1 (SIKE1) is a protein from Homo sapiens identified by UniProt accession Q9BRV8, 207 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9BRV8; gene symbol SIKE1.
- Organism: Homo sapiens.
- Length: 207 amino acids.
- Top disease associations (Open Targets): severe acute respiratory syndrome, urinary bladder cancer and cardiac hypertrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of IKBKE 1 |
|---|---|
| UniProt accession | Q9BRV8 |
| Gene | SIKE1 |
| Organism | Homo sapiens |
| Length | 207 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- urinary bladder cancer · score 0.09
- cardiac hypertrophy · score 0.07
- body mass index · score 0.06
- age at first sexual intercourse measurement · score 0.04
- non-alcoholic steatohepatitis · score 0.01
- psoriasis · score 0.01
- Dilated cardiomyopathy · score 0.01
- hypertrophic cardiomyopathy · score 0.01
- insulin resistance · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRV8-F1 | alphafold | PREDICTED | 85.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRV8.
Amino-acid sequence (207 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIKE1?
The strongest Open Targets associations for SIKE1 are severe acute respiratory syndrome, urinary bladder cancer, cardiac hypertrophy, body mass index and age at first sexual intercourse measurement.
How long is the SIKE1 protein?
The Homo sapiens SIKE1 protein (UniProt Q9BRV8) is 207 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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