DNA replication complex GINS protein PSF3 (GINS3)
Homo sapiens — UniProt Q9BRX5
Data last refreshed: (UniProt release unknown)
Key facts
DNA replication complex GINS protein PSF3 (GINS3) is a protein from Homo sapiens identified by UniProt accession Q9BRX5, 216 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9BRX5; gene symbol GINS3.
- Organism: Homo sapiens.
- Length: 216 amino acids.
- Top disease associations (Open Targets): Meier-Gorlin syndrome, endometrial cancer and urinary bladder cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA replication complex GINS protein PSF3 |
|---|---|
| UniProt accession | Q9BRX5 |
| Gene | GINS3 |
| Organism | Homo sapiens |
| Length | 216 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- Meier-Gorlin syndrome · score 0.37
- endometrial cancer · score 0.14
- urinary bladder cancer · score 0.10
- cancer · score 0.06
- electrocardiography · score 0.05
- neoplasm · score 0.04
- squamous cell carcinoma · score 0.04
- drug use measurement · score 0.04
- TPE interval measurement · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BRX5-F1 | alphafold | PREDICTED | 87.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BRX5.
Amino-acid sequence (216 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GINS3?
The strongest Open Targets associations for GINS3 are Meier-Gorlin syndrome, endometrial cancer, urinary bladder cancer, cancer and electrocardiography.
How long is the GINS3 protein?
The Homo sapiens GINS3 protein (UniProt Q9BRX5) is 216 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BRX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BRX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.