Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (HERPUD2)
Homo sapiens — UniProt Q9BSE4
Data last refreshed: (UniProt release unknown)
Key facts
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (HERPUD2) is a protein from Homo sapiens identified by UniProt accession Q9BSE4, 406 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9BSE4; gene symbol HERPUD2.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): apolipoprotein A 1 measurement, serum gamma-glutamyl transferase measurement and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein |
|---|---|
| UniProt accession | Q9BSE4 |
| Gene | HERPUD2 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.25
- electrocardiography · score 0.21
- PR interval · score 0.20
- cirrhosis of liver · score 0.17
- non-alcoholic fatty liver disease · score 0.17
- platelet crit · score 0.16
- platelet count · score 0.11
- diastolic blood pressure · score 0.11
- carotid artery intima media thickness · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSE4-F1 | alphafold | PREDICTED | 60.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSE4.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HERPUD2?
The strongest Open Targets associations for HERPUD2 are apolipoprotein A 1 measurement, serum gamma-glutamyl transferase measurement, electrocardiography, PR interval and cirrhosis of liver.
How long is the HERPUD2 protein?
The Homo sapiens HERPUD2 protein (UniProt Q9BSE4) is 406 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSE4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSE4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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