Guanidino acid hydrolase, mitochondrial (AGMAT)
Homo sapiens — UniProt Q9BSE5
Data last refreshed: (UniProt release unknown)
Key facts
Guanidino acid hydrolase, mitochondrial (AGMAT) is a protein from Homo sapiens identified by UniProt accession Q9BSE5, 352 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q9BSE5; gene symbol AGMAT.
- Organism: Homo sapiens.
- Length: 352 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, creatinine measurement and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanidino acid hydrolase, mitochondrial |
|---|---|
| UniProt accession | Q9BSE5 |
| Gene | AGMAT |
| Organism | Homo sapiens |
| Length | 352 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- creatinine measurement · score 0.25
- high density lipoprotein cholesterol measurement · score 0.23
- cystatin C measurement · score 0.22
- triglyceride measurement · score 0.19
- serum metabolite measurement · score 0.18
- hemoglobin measurement · score 0.17
- urinary metabolite measurement · score 0.16
- glomerular filtration rate · score 0.16
- urate measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSE5-F1 | alphafold | PREDICTED | 91.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSE5.
Amino-acid sequence (352 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGMAT?
The strongest Open Targets associations for AGMAT are neurodegenerative disease, creatinine measurement, high density lipoprotein cholesterol measurement, cystatin C measurement and triglyceride measurement.
How long is the AGMAT protein?
The Homo sapiens AGMAT protein (UniProt Q9BSE5) is 352 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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