TERF1-interacting nuclear factor 2 (TINF2)
Homo sapiens — UniProt Q9BSI4
Data last refreshed: (UniProt release unknown)
Key facts
TERF1-interacting nuclear factor 2 (TINF2) is a protein from Homo sapiens identified by UniProt accession Q9BSI4, 451 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q9BSI4; gene symbol TINF2.
- Organism: Homo sapiens.
- Length: 451 amino acids.
- Top disease associations (Open Targets): dyskeratosis congenita, autosomal dominant 3, Revesz syndrome and dyskeratosis congenita.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TERF1-interacting nuclear factor 2 |
|---|---|
| UniProt accession | Q9BSI4 |
| Gene | TINF2 |
| Organism | Homo sapiens |
| Length | 451 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita, autosomal dominant 3 · score 0.79
- Revesz syndrome · score 0.78
- dyskeratosis congenita · score 0.72
- neurodegenerative disease · score 0.53
- Hoyeraal-Hreidarsson syndrome · score 0.37
- head and neck squamous cell carcinoma · score 0.26
- endometrial cancer · score 0.24
- glioblastoma multiforme · score 0.23
- gastric adenocarcinoma · score 0.21
- lung adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSI4-F1 | alphafold | PREDICTED | 60.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSI4.
Amino-acid sequence (451 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TINF2?
The strongest Open Targets associations for TINF2 are dyskeratosis congenita, autosomal dominant 3, Revesz syndrome, dyskeratosis congenita, neurodegenerative disease and Hoyeraal-Hreidarsson syndrome.
How long is the TINF2 protein?
The Homo sapiens TINF2 protein (UniProt Q9BSI4) is 451 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSI4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSI4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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