Extended synaptotagmin-1 (ESYT1)
Homo sapiens — UniProt Q9BSJ8
Data last refreshed: (UniProt release unknown)
Key facts
Extended synaptotagmin-1 (ESYT1) is a protein from Homo sapiens identified by UniProt accession Q9BSJ8, 1104 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9BSJ8; gene symbol ESYT1.
- Organism: Homo sapiens.
- Length: 1104 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, self reported educational attainment and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Extended synaptotagmin-1 |
|---|---|
| UniProt accession | Q9BSJ8 |
| Gene | ESYT1 |
| Organism | Homo sapiens |
| Length | 1104 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- self reported educational attainment · score 0.15
- lean body mass · score 0.11
- fat body mass · score 0.10
- base metabolic rate measurement · score 0.08
- whole body water mass · score 0.08
- glioblastoma multiforme · score 0.07
- body weight · score 0.07
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.06
- Hypomaturation amelogenesis imperfecta · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSJ8-F1 | alphafold | PREDICTED | 77.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSJ8.
Amino-acid sequence (1104 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ESYT1?
The strongest Open Targets associations for ESYT1 are neurodegenerative disease, self reported educational attainment, lean body mass, fat body mass and base metabolic rate measurement.
How long is the ESYT1 protein?
The Homo sapiens ESYT1 protein (UniProt Q9BSJ8) is 1104 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSJ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSJ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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