Cerebral cavernous malformations 2 protein (CCM2)
Homo sapiens — UniProt Q9BSQ5
Data last refreshed: (UniProt release unknown)
Key facts
Cerebral cavernous malformations 2 protein (CCM2) is a protein from Homo sapiens identified by UniProt accession Q9BSQ5, 444 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9BSQ5; gene symbol CCM2.
- Organism: Homo sapiens.
- Length: 444 amino acids.
- Top disease associations (Open Targets): famililal cerebral cavernous malformations, cerebral cavernous malformation and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cerebral cavernous malformations 2 protein |
|---|---|
| UniProt accession | Q9BSQ5 |
| Gene | CCM2 |
| Organism | Homo sapiens |
| Length | 444 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- famililal cerebral cavernous malformations · score 0.73
- cerebral cavernous malformation · score 0.45
- neurodegenerative disease · score 0.36
- diastolic blood pressure · score 0.36
- Cavernous Hemangioma · score 0.34
- neutrophil count · score 0.33
- eosinophil count · score 0.33
- platelet count · score 0.32
- myeloid white cell count · score 0.30
- platelet crit · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSQ5-F1 | alphafold | PREDICTED | 66.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSQ5.
Amino-acid sequence (444 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCM2?
The strongest Open Targets associations for CCM2 are famililal cerebral cavernous malformations, cerebral cavernous malformation, neurodegenerative disease, diastolic blood pressure and Cavernous Hemangioma.
How long is the CCM2 protein?
The Homo sapiens CCM2 protein (UniProt Q9BSQ5) is 444 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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