tRNA-splicing endonuclease subunit Sen34 (TSEN34)
Homo sapiens — UniProt Q9BSV6
Data last refreshed: (UniProt release unknown)
Key facts
tRNA-splicing endonuclease subunit Sen34 (TSEN34) is a protein from Homo sapiens identified by UniProt accession Q9BSV6, 310 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q9BSV6; gene symbol TSEN34.
- Organism: Homo sapiens.
- Length: 310 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia type 2, pontocerebellar hypoplasia and Non-syndromic pontocerebellar hypoplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA-splicing endonuclease subunit Sen34 |
|---|---|
| UniProt accession | Q9BSV6 |
| Gene | TSEN34 |
| Organism | Homo sapiens |
| Length | 310 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 2 · score 0.67
- pontocerebellar hypoplasia · score 0.51
- Non-syndromic pontocerebellar hypoplasia · score 0.19
- body height · score 0.14
- phosphatidylinositol measurement · score 0.05
- Takayasu arteritis · score 0.04
- intellectual disability, autosomal recessive 57 · score 0.01
- IGA glomerulonephritis · score 0.00
- COVID-19 · score 0.00
- Microcephaly · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSV6-F1 | alphafold | PREDICTED | 83.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSV6.
Amino-acid sequence (310 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSEN34?
The strongest Open Targets associations for TSEN34 are pontocerebellar hypoplasia type 2, pontocerebellar hypoplasia, Non-syndromic pontocerebellar hypoplasia, body height and phosphatidylinositol measurement.
How long is the TSEN34 protein?
The Homo sapiens TSEN34 protein (UniProt Q9BSV6) is 310 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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