Deubiquitinase DESI2 (DESI2)
Homo sapiens — UniProt Q9BSY9
Data last refreshed: (UniProt release unknown)
Key facts
Deubiquitinase DESI2 (DESI2) is a protein from Homo sapiens identified by UniProt accession Q9BSY9, 194 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9BSY9; gene symbol DESI2.
- Organism: Homo sapiens.
- Length: 194 amino acids.
- Top disease associations (Open Targets): viral load, cancer and pancreatic ductal adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deubiquitinase DESI2 |
|---|---|
| UniProt accession | Q9BSY9 |
| Gene | DESI2 |
| Organism | Homo sapiens |
| Length | 194 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- viral load · score 0.18
- cancer · score 0.08
- pancreatic ductal adenocarcinoma · score 0.04
- hepatocellular carcinoma · score 0.03
- ovarian carcinoma · score 0.02
- neoplasm · score 0.01
- Abnormal sperm morphology · score 0.01
- Pick disease · score 0.01
- glioblastoma multiforme · score 0.01
- skin squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BSY9-F1 | alphafold | PREDICTED | 85.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BSY9.
Amino-acid sequence (194 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DESI2?
The strongest Open Targets associations for DESI2 are viral load, cancer, pancreatic ductal adenocarcinoma, hepatocellular carcinoma and ovarian carcinoma.
How long is the DESI2 protein?
The Homo sapiens DESI2 protein (UniProt Q9BSY9) is 194 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BSY9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BSY9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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