About WW domain-containing adapter protein with coiled-coil
WW domain-containing adapter protein with coiled-coil (WAC) is a protein
from Homo sapiens identified by UniProt accession
Q9BTA9, 647 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | WW domain-containing adapter protein with coiled-coil |
|---|
| UniProt accession | Q9BTA9 |
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| Gene | WAC |
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| Organism | Homo sapiens |
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| Length | 647 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- DeSanto-Shinawi syndrome due to WAC point mutation · score 0.70
- 10p11.21p12.31 microdeletion syndrome · score 0.66
- DeSanto-Shinawi syndrome · score 0.52
- genetic disorder · score 0.49
- Neurodevelopmental disorder · score 0.41
- Intellectual disability · score 0.37
- Neurodevelopmental delay · score 0.34
- mean corpuscular volume · score 0.32
- body height · score 0.31
- basophil count · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BTA9-F1 | alphafold | PREDICTED | 54.83 | — |
Amino-acid sequence (647 residues)
MVMYARKQQR LSDGCHDRRG DSQPYQALKY SSKSHPSSGD HRHEKMRDAG DPSPPNKMLR RSDSPENKYS DSTGHSKAKN VHTHRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKMAVNS FPKDRDYRRE VMQATATSGF ASGMEDKHSS DASSLLPQNI LSQTSRHNDR DYRLPRAETH SSSTPVQHPI KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTSSVPA QKTERKESTS GDKPVSHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ SPIPPLLQDP NLLRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ SIIHKFLTAG PSAFNITSLI SQAAQLSTQA QPSNQSPMSL TSDASSPRSY VSPRISTPQT NTVPIKPLIS TPPVSSQPKV STPVVKQGPV SQSATQQPVT ADKQQGHEPV SPRSLQRSSS QRSPSPGPNH TSNSSNASNA TVVPQNSSAR STCSLTPALA AHFSENLIKH VQGWPADHAE KQASRLREEA HNMGTIHMSE ICTELKNLRS LVRVCEIQAT LREQRILFLR QQIKELEKLK NQNSFMV
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