WW domain-containing adapter protein with coiled-coil (WAC)
Homo sapiens — UniProt Q9BTA9
Data last refreshed: (UniProt release unknown)
Key facts
WW domain-containing adapter protein with coiled-coil (WAC) is a protein from Homo sapiens identified by UniProt accession Q9BTA9, 647 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q9BTA9; gene symbol WAC.
- Organism: Homo sapiens.
- Length: 647 amino acids.
- Top disease associations (Open Targets): DeSanto-Shinawi syndrome due to WAC point mutation, 10p11.21p12.31 microdeletion syndrome and DeSanto-Shinawi syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WW domain-containing adapter protein with coiled-coil |
|---|---|
| UniProt accession | Q9BTA9 |
| Gene | WAC |
| Organism | Homo sapiens |
| Length | 647 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- DeSanto-Shinawi syndrome due to WAC point mutation · score 0.70
- 10p11.21p12.31 microdeletion syndrome · score 0.66
- DeSanto-Shinawi syndrome · score 0.52
- genetic disorder · score 0.49
- Neurodevelopmental disorder · score 0.41
- Intellectual disability · score 0.37
- Neurodevelopmental delay · score 0.34
- mean corpuscular volume · score 0.32
- body height · score 0.31
- basophil count · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BTA9-F1 | alphafold | PREDICTED | 54.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTA9.
Amino-acid sequence (647 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WAC?
The strongest Open Targets associations for WAC are DeSanto-Shinawi syndrome due to WAC point mutation, 10p11.21p12.31 microdeletion syndrome, DeSanto-Shinawi syndrome, genetic disorder and Neurodevelopmental disorder.
How long is the WAC protein?
The Homo sapiens WAC protein (UniProt Q9BTA9) is 647 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BTA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BTA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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