PAXIP1-associated glutamate-rich protein 1 (PAGR1)
Homo sapiens — UniProt Q9BTK6
Data last refreshed: (UniProt release unknown)
Key facts
PAXIP1-associated glutamate-rich protein 1 (PAGR1) is a protein from Homo sapiens identified by UniProt accession Q9BTK6, 254 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9BTK6; gene symbol PAGR1.
- Organism: Homo sapiens.
- Length: 254 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, head and neck squamous cell carcinoma and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PAXIP1-associated glutamate-rich protein 1 |
|---|---|
| UniProt accession | Q9BTK6 |
| Gene | PAGR1 |
| Organism | Homo sapiens |
| Length | 254 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.22
- head and neck squamous cell carcinoma · score 0.15
- mean platelet volume · score 0.15
- multiple sclerosis · score 0.06
- infect · score 0.03
- infection · score 0.03
- neoplasm · score 0.02
- Neurodevelopmental disorder · score 0.01
- cancer · score 0.01
- Invasive Breast Carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BTK6-F1 | alphafold | PREDICTED | 62.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTK6.
Amino-acid sequence (254 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAGR1?
The strongest Open Targets associations for PAGR1 are breast adenocarcinoma, head and neck squamous cell carcinoma, mean platelet volume, multiple sclerosis and infect.
How long is the PAGR1 protein?
The Homo sapiens PAGR1 protein (UniProt Q9BTK6) is 254 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BTK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BTK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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