Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3)
Homo sapiens — UniProt Q9BTN0
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (LRFN3) is a protein from Homo sapiens identified by UniProt accession Q9BTN0, 628 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9BTN0; gene symbol LRFN3.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Top disease associations (Open Targets): thyroid gland adenocarcinoma, lung adenocarcinoma and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and fibronectin type-III domain-containing protein 3 |
|---|---|
| UniProt accession | Q9BTN0 |
| Gene | LRFN3 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.18
- lung adenocarcinoma · score 0.18
- calcium measurement · score 0.11
- isolated congenital hypogonadotropic hypogonadism · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- azoospermia · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.06
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.05
- familial male-limited precocious puberty · score 0.05
- Testicular regression syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BTN0-F1 | alphafold | PREDICTED | 77.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTN0.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRFN3?
The strongest Open Targets associations for LRFN3 are thyroid gland adenocarcinoma, lung adenocarcinoma, calcium measurement, isolated congenital hypogonadotropic hypogonadism and 46,XX testicular disorder of sex development.
How long is the LRFN3 protein?
The Homo sapiens LRFN3 protein (UniProt Q9BTN0) is 628 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BTN0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BTN0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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