Diphthine methyltransferase (DPH7)
Homo sapiens — UniProt Q9BTV6
Data last refreshed: (UniProt release unknown)
Key facts
Diphthine methyltransferase (DPH7) is a protein from Homo sapiens identified by UniProt accession Q9BTV6, 452 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9BTV6; gene symbol DPH7.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, asthma and prostate carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Diphthine methyltransferase |
|---|---|
| UniProt accession | Q9BTV6 |
| Gene | DPH7 |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- asthma · score 0.13
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- atopic eczema · score 0.04
- body mass index · score 0.02
- lower respiratory tract disease · score 0.02
- sleep duration · score 0.02
- chronic obstructive pulmonary disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BTV6-F1 | alphafold | PREDICTED | 80.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTV6.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPH7?
The strongest Open Targets associations for DPH7 are neurodegenerative disease, asthma, prostate carcinoma, Familial prostate cancer and prostate cancer.
How long is the DPH7 protein?
The Homo sapiens DPH7 protein (UniProt Q9BTV6) is 452 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BTV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BTV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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