Tubulin-specific chaperone D (TBCD)
Homo sapiens — UniProt Q9BTW9
Data last refreshed: (UniProt release unknown)
Key facts
Tubulin-specific chaperone D (TBCD) is a protein from Homo sapiens identified by UniProt accession Q9BTW9, 1192 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9BTW9; gene symbol TBCD.
- Organism: Homo sapiens.
- Length: 1192 amino acids.
- Top disease associations (Open Targets): early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome, PEHO syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tubulin-specific chaperone D |
|---|---|
| UniProt accession | Q9BTW9 |
| Gene | TBCD |
| Organism | Homo sapiens |
| Length | 1192 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome · score 0.83
- PEHO syndrome · score 0.56
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.41
- seborrhea-like dermatitis with psoriasiform elements · score 0.36
- HbA1c measurement · score 0.24
- mean platelet volume · score 0.21
- platelet component distribution width · score 0.21
- metabolite measurement · score 0.19
- lung adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BTW9-F1 | alphafold | PREDICTED | 90.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTW9.
Amino-acid sequence (1192 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBCD?
The strongest Open Targets associations for TBCD are early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome, PEHO syndrome, neurodegenerative disease, genetic disorder and seborrhea-like dermatitis with psoriasiform elements.
How long is the TBCD protein?
The Homo sapiens TBCD protein (UniProt Q9BTW9) is 1192 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BTW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BTW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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