Alpha-tocopherol transfer protein-like (TTPAL)

About Alpha-tocopherol transfer protein-like

Alpha-tocopherol transfer protein-like (TTPAL) is a protein from Homo sapiens identified by UniProt accession Q9BTX7, 342 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Alpha-tocopherol transfer protein-like
UniProt accession	Q9BTX7
Gene	TTPAL
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

gonorrhea · score 0.07
ulcerative colitis · score 0.07
inflammatory bowel disease · score 0.06
sex hormone-binding globulin measurement · score 0.06
testosterone measurement · score 0.05
neoplasm · score 0.05
urate measurement · score 0.05
serum gamma-glutamyl transferase measurement · score 0.05
high density lipoprotein cholesterol measurement · score 0.04
cholelithiasis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BTX7-F1	alphafold	PREDICTED	85.31	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BTX7.

Amino-acid sequence (342 residues)

MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK PEWRLRDVQA LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV NYHSCRRSWP EVFNNLKPSA LKDVLASGFL TVLPHTDPRG CHVVCIRPDR WIPSNYPITE NIRAIYLTLE KLIQSEETQV NGIVILADYK GVSLSKASHF GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK PFLKEKIANR FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards