Methyltransferase-like protein 22 (METTL22)
Homo sapiens — UniProt Q9BUU2
Data last refreshed: (UniProt release unknown)
Key facts
Methyltransferase-like protein 22 (METTL22) is a protein from Homo sapiens identified by UniProt accession Q9BUU2, 404 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9BUU2; gene symbol METTL22.
- Organism: Homo sapiens.
- Length: 404 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, chronotype measurement and refractive error.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methyltransferase-like protein 22 |
|---|---|
| UniProt accession | Q9BUU2 |
| Gene | METTL22 |
| Organism | Homo sapiens |
| Length | 404 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- chronotype measurement · score 0.10
- refractive error · score 0.10
- monocyte count · score 0.09
- vital capacity · score 0.08
- hypertriglyceridemia 2 · score 0.07
- cholesterol-ester transfer protein deficiency · score 0.06
- forced expiratory volume · score 0.06
- thyroid hormone metabolism, abnormal, 2 · score 0.05
- sitosterolemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BUU2-F1 | alphafold | PREDICTED | 77.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BUU2.
Amino-acid sequence (404 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL22?
The strongest Open Targets associations for METTL22 are neurodegenerative disease, chronotype measurement, refractive error, monocyte count and vital capacity.
How long is the METTL22 protein?
The Homo sapiens METTL22 protein (UniProt Q9BUU2) is 404 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BUU2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BUU2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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