Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)
Homo sapiens — UniProt Q9BUX1
Data last refreshed: (UniProt release unknown)
Key facts
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) is a protein from Homo sapiens identified by UniProt accession Q9BUX1, 222 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9BUX1; gene symbol CHAC1.
- Organism: Homo sapiens.
- Length: 222 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, systolic blood pressure and macula measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glutathione-specific gamma-glutamylcyclotransferase 1 |
|---|---|
| UniProt accession | Q9BUX1 |
| Gene | CHAC1 |
| Organism | Homo sapiens |
| Length | 222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.28
- systolic blood pressure · score 0.27
- macula measurement · score 0.13
- body mass index · score 0.13
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- BMI-adjusted waist circumference · score 0.10
- neoplasm · score 0.10
- Helicobacter pylori infectious disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BUX1-F1 | alphafold | PREDICTED | 84.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BUX1.
Amino-acid sequence (222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHAC1?
The strongest Open Targets associations for CHAC1 are diastolic blood pressure, systolic blood pressure, macula measurement, body mass index and Familial prostate cancer.
How long is the CHAC1 protein?
The Homo sapiens CHAC1 protein (UniProt Q9BUX1) is 222 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BUX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BUX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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